Phoenixin-14 TFA

Description: Phoenixin-14 TFA (PNX-14) is a blood-brain barrier (BBB)-penetrable neuropeptide with anxiolytic, cardioprotective, and neuroprotective properties. It modulates pituitary gonadotrophin release by enhancing gonadotropin-releasing hormone (GnRH) receptor mRNA expression and promotes insulin secretion. Additionally, PNX-14 TFA protects against ischemia/reperfusion (IR) injury in mice and combats oxidative stress by diminishing reactive oxygen species (ROS) and elevating glutathione (GSH) levels [1] [2] [3]. Target: GNRH Receptor. Smiles: [H]N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@@H](CC(O)=O)C(N5CCC[C@H]5C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)CO)=O)=O)C(C)C)=O)CCCCN)=O)CC(C)C)=O)=O)=O)=O)CCC(N)=O)=O)C(C)C)=O.OC(C(F)(F)F)=O. References: Ma H, et al. Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia. Arch Biochem Biophys. 2020 Aug 15,689:108411.