PAR4 (1-6) (mouse) (trifluoroacetate salt)

PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4, EC50 = 30 µM in Xenopus oocytes expressing human PAR4 receptors) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence. It induces calcium release in wild-type and PAR3-/- mouse platelets and in human platelets but has no activity in Xenopus oocytes expressing human PAR1. PAR4 (1-6) also triggers [3H]inositol phosphate release from KOLF cells expressing human PAR4.Formal Name: glycyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine, trifluoroacetate salt. Synonyms: GYPGKF, H-Gly-Tyr-Pro-Gly-Lys-Phe-OH. Molecular Formula: C33H45N7O8 . XCF3COOH. Formula Weight: 667.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: OC(C(F)(F)F)=O.[H]NCC(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O. InChi Code: InChI=1S/C33H45N7O8.C2HF3O2/c34-15-5-4-9-24(30(44)39-26(33(47)48)18-21-7-2-1-3-8-21)37-29(43)20-36-31(45)27-10-6-16-40(27)32(46)25(38-28(42)19-35)17-22-11-13-23(41)14-12-22,3-2(4,5)1(6)7/h1-3,7-8,11-14,24-27,41H,4-6,9-10,15-20,34-35H2,(H,36,45)(H,37,43)(H,38,42)(H,39,44)(H,47,48),(H,6,7)/t24-,25-,26-,27-,/m0./s1. InChi Key: XNLKRKZRBQFCSH-LQHVCSEWSA-N.