PapRIV (trifluoroacetate salt)

PapRIV is a quorum-sensing heptapeptide originally isolated from B. cereus. It is translated as a 48-amino acid polypeptide, which is secreted and extracellularly processed by NprB proteases to form the active heptapeptide. PapRIV (1-25 µM) induces IL-6 and TNF-alpha production by, and NF-kappaB translocation in, BV-2 microglia cells.Formal Name: (S)-4-((S)-2-((S)-1-(L-seryl-L-aspartyl-L-leucyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-(((S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl)amino)-5-oxopentanoic acid. Molecular Formula: C38H53N9O13 . XCF3COOH. Formula Weight: 843.9. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: SDLPFEH-OH. Solubility: Water: soluble. SMILES: O=C([C@@H](N)CO)N[C@H](C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(O)=O)CC3=CNC=N3)=O)CCC(O)=O)=O)=O)=O)=O)CC(O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C38H53N9O13.C2HF3O2/c1-20(2)13-27(45-35(56)26(16-31(51)52)43-32(53)23(39)18-48)37(58)47-12-6-9-29(47)36(57)44-25(14-21-7-4-3-5-8-21)34(55)42-24(10-11-30(49)50)33(54)46-28(38(59)60)15-22-17-40-19-41-22,3-2(4,5)1(6)7/h3-5,7-8,17,19-20,23-29,48H,6,9-16,18,39H2,1-2H3,(H,40,41)(H,42,55)(H,43,53)(H,44,57)(H,45,56)(H,46,54)(H,49,50)(H,51,52)(H,59,60),(H,6,7)/t23-,24-,25-,26-,27-,28-,29-,/m0./s1. InChi Key: JGBRZAJJPGVQEE-WXZWFHAESA-N.