Neurotensin (8-13) (trifluoroacetate salt)

Neurotensin (8-13) is a neuropeptide that corresponds to the C-terminal residues 8-13 of neurotensin (Cay-24717) that binds to rat synaptic membranes with a Ki value of 13 nM. It induces contraction of guinea pig ileum (EC50 = 25 nM) and induces contraction of rat fundus equipotently to full length neurotensin (EC50s = 1.29 and 1.58 nM, respectively). In vivo, neurotensin (8-13) has antinociceptive effects in a mouse tail pressure test (ED50 = 50 nmol per animal). It induces extracellular dopamine release in the prefrontal cortex in rats. Neurotensin (8-13) also decreases diastolic blood pressure in a dose-dependent manner in normotensive rats without affecting heart rate.Formal Name: L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine, trifluoroacetate salt. Molecular Formula: C38H64N12O8 . XCF3COOH. Formula Weight: 817.0. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C38H64N12O8.C2HF3O2/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41,3-2(4,5)1(6)7/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45),(H,6,7)/t22-,25-,26-,27-,28-,29-,30-,/m0./s1. InChi Key: HOEZVADMUNOUHK-IUBGQBINSA-N.