Neuromedin U-25 (human)

Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide (or PI) signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 (ILC2) during inflammation, as shown in studies in mice [6-8].