MBP Isoform 1, human Peptide Pool

Pool of 74 peptides derived from a peptide scan (15mers with 11 aa overlap) through Myelin basic protein (Uni-Prot ID P02686-1) of Homo sapiens (Human). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. [The UniProt Consortium]