Mastoparan X (trifluoroacetate salt)

Mastoparan X is an antimicrobial peptide that has been found in wasp venom. It is active against several Gram-positive and Gram-negative bacteria (MICs = 3-64 and 4-256 µg/ml, respectively) and induces permeabilization of E. coli cytoplasmic membranes by 86% when used at a concentration of 6.4 µg/ml. Mastoparan X induces GDP/GTP exchange by Gi in a concentration-dependent manner and binds to calmodulin (Kd = ~0.9 nM) in cell-free assays. It induces necrosis in T98G glioblastoma multiforme (GBM) cells when used at a concentration of 20 µM. Mastoparan X (128 µg/ml) induces degranulation of isolated rat peritoneal mast cells and hemolysis of isolated sheep, chicken, and human erythrocytes in a concentration-dependent manner. In vivo, mastoparan X (20 mg/kg) increases survival, decreases disease severity, and prevents damage to jejunal villi and crypts in a mouse model of enterohemorrhagic E. coli infection.Formal Name: L-isoleucyl-L-asparaginyl-L-tryptophyl-L-lysylglycyl-L-isoleucyl-L-alanyl-L-alanyl-L-methionyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-leucinamide, trifluoroacetate salt. CAS Number: 72093-22-2. Synonyms: Mastoparan V, MPV, MPX. Molecular Formula: C73H126N20O15S . XCF3COOH. Formula Weight: 1556.0. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: INWKGIAAMAKKLL-NH2. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 221 nm. SMILES: CC[C@H](C)[C@H](N)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CCCCN)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C73H126N20O15S.C2HF3O2/c1-13-41(7)59(78)72(107)92-56(36-57(77)94)71(106)91-55(35-46-37-80-48-24-16-15-23-47(46)48)70(105)87-49(25-17-20-29-74)65(100)81-38-58(95)93-60(42(8)14-2)73(108)84-43(9)62(97)82-44(10)63(98)86-52(28-32-109-12)66(101)83-45(11)64(99)85-50(26-18-21-30-75)67(102)88-51(27-19-22-31-76)68(103)90-54(34-40(5)6)69(104)89-53(61(79)96)33-39(3)4,3-2(4,5)1(6)7/h15-16,23-24,37,39-45,49-56,59-60,80H,13-14,17-22,25-36,38,74-76,78H2,1-12H3,(H2,77,94)(H2,79,96)(H,81,100)(H,82,97)(H,83,101)(H,84,108)(H,85,99)(H,86,98)(H,87,105)(H,88,102)(H,89,104)(H,90,103)(H,91,106)(H,92,107)(H,93,95),(H,6,7)/t41-,42-,43-,44-,45-,49-,50-,51-,52-,53-,54-,55-,56-,59-,60-,/m0./s1. InChi Key: UOGNJCLOQPJALD-VAYWNKABSA-N. Origin: Synthetic.