M871 (trifluoroacetate salt)

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Item number	Size	Manual	Delivery time	Price
Cay42403-1	1 mg	-	6 - 10 business days*	103.00€
Cay42403-5	5 mg	-	6 - 10 business days*	488.00€
Cay42403-10	10 mg	-	6 - 10 business days*	772.00€

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M871 is a peptide antagonist of galanin-2 (GAL2) receptors (Ki = 13. nM). It is selective for... more

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Product information "M871 (trifluoroacetate salt)"

M871 is a peptide antagonist of galanin-2 (GAL2) receptors (Ki = 13. nM). It is selective for GAL2 receptors over GAL1 receptors (Ki = 420 nM). M871 (0. 1, or 10 nM) inhibits galanin-induced increases in inositol levels in CHO cells expressing human GAL2 receptors. It increases blood glucose, IL-8, IL-6, IL-22, and Tnf-alpha levels and decreases skeletal muscle and adipocyte glucose transporter 4 (Glut4) and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (Pgc-1alpha) levels in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ, Cay-13104) when administered intracerebroventricularly.. Solulibility: DMSO: Soluble: =10 mg/ml: Ethanol: Slightly Soluble: 0.1-1 mg/ml, PBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml.

Keywords:	L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-a-glutamyl-L-histidyl-L-prolyl-L-prolyl-L-prolyl-L-alanyl-L-leucyl-L-alanyl-L-leucyl-L-alaninamide, trifluoroacetate salt
Supplier:	Cayman Chemical
Supplier-Nr:	42403