M. tuberculosis esxB CFP-10 Peptide Pool

Pool of 23 peptides derived from a peptide scan (15mers with 11 aa overlap) through ESAT-6-like protein (Uni-Prot ID: P9WNK5) - EsxB of M. Tuberculosis - strain ATCC 25618 / H37Rv. One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA, native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils, EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS), Ca(2+) release and the ROS burst via are induced by an unidentified G- protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). [The UniProt Consortium]