LIH383 (trifluoroacetate salt)

LIH383 is a peptide agonist of chemokine (C-X-C motif) receptor 7 (CXCR7), a chemokine and opioid peptide scavenger receptor. It selectively activates CXCR7 (EC50 = 0.61 nM) over µ-, delta-, and kappa-opioid receptors and the nociceptin opioid peptide (NOP) receptor in beta-arrestin recruitment assays at 3 µM. LIH383 (3 µM) prevents CXCR7 uptake of opioid peptides induced by the non-selective opioid receptor agonist dynorphin A (Cay-18169) in U87-ACKR3 cells.Formal Name: (S)-6-amino-2-((2S,5S,8S,11S,20S)-20-amino-11-benzyl-2,5-bis(3-guanidinopropyl)-8-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-21-phenyl-3,6,9,12,15,18-hexaazahenicosanamido)hexanamide, trifluoroacetate salt. Synonyms: Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2. Molecular Formula: C45H72N16O8S . XCF3COOH. Formula Weight: 997.2. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: FGGFMRRK-NH2. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC(C(F)(F)F)=O.O=C([C@H](CC1=CC=CC=C1)N)NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCSC)=O)=O)=O. InChi Code: InChI=1S/C45H72N16O8S.C2HF3O2/c1-70-23-19-34(61-43(69)35(25-29-14-6-3-7-15-29)57-37(63)27-55-36(62)26-56-39(65)30(47)24-28-12-4-2-5-13-28)42(68)60-33(18-11-22-54-45(51)52)41(67)59-32(17-10-21-53-44(49)50)40(66)58-31(38(48)64)16-8-9-20-46,3-2(4,5)1(6)7/h2-7,12-15,30-35H,8-11,16-27,46-47H2,1H3,(H2,48,64)(H,55,62)(H,56,65)(H,57,63)(H,58,66)(H,59,67)(H,60,68)(H,61,69)(H4,49,50,53)(H4,51,52,54),(H,6,7)/t30-,31-,32-,33-,34-,35-,/m0./s1. InChi Key: NDERINDLRSIQOH-SKTOPIDTSA-N.