L57

Description: L57 is a high affinity low-density lipoprotein receptor-related protein 1 (LRP1) with a Ki value of 45 nM. The compound has excellent blood-brain barrier (BBB) permeability and plasma stability and can be used as a carrier for central nervous system drug delivery. Smiles: C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC7=CN=CN7)C(O)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)[C@H](CC)C)=O)CO)=O)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)CC(O)=O)=O)=O)=O)CCCCN)=O)CCC1)NC([C@H]([C@@H](C)O)N)=O)C=8C=9C(NC8)=CC=CC9