L-Leucyl-L-Leucine methyl ester (hydrochloride)

L-Leucyl-L-Leucine methyl ester (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16008-100 100 mg -

5 - 10 business days*

Cay16008-250 250 mg -

5 - 10 business days*

Cay16008-1 1 g -

5 - 10 business days*

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported... more
Product information "L-Leucyl-L-Leucine methyl ester (hydrochloride)"
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.
Keywords: LLME, LLOMe, L-leucyl-L-leucine, methyl ester, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 16008


Application: Specific cytotoxin
Conjugate: No
MW: 294.8 D
Formula: C13H26N2O3 . HCl
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 6491-83-4| Find alternatives
KEGG ID : K01275 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H312, H332
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P361+P364, P501
Our products are for laboratory research use only: Not for administration to humans!
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