Klotho-derived Peptide 1 (56-87) (human) (trifluoroacetate salt)

Klotho-derived peptide 1 (KP1) (56-87) is a peptide derived from human Klotho protein, which has roles in disrupting TGF-beta signaling. It binds to TGF-beta receptor type 1 (TGFBR2), and TGF-beta receptor type 2 (TGFBR2, Kds = 1.41 and 14.6 µM, respectively). Preincubation with KP1 (10 µg/ml) inhibits TGF-beta-induced increases in fibronectin and alpha-smooth muscle actin (alpha-SMA) levels in NRK-49F rat fibroblasts. In vivo, KP1 (1 mg/kg per day) selectively localizes to damaged kidneys and reduces serum creatine and blood urea nitrogen levels, markers of kidney function, as well as reduces kidney fibrosis, in mouse models of unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion injury-induced renal fibrosis.Synonyms: KP1 (56-87). Molecular Formula: C149H203N39O43 . XCF3COOH. Formula Weight: 3228.4. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG-OH. Solubility: Water: Soluble. SMILES: [H]N[C@H](C(N[C@@H](CCC(N)=O)C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)C)=O)C)=O)=O)=O)=O)C)=O)CC6=CNC7=C6C=CC=C7)=O)=O)CC8=CC=CC=C8)=O)=O)CC(O)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)CC%10=CC=CC=C%10.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C149H203N39O43.C2HF3O2/c1-75(2)54-101(180-141(223)102(56-83-28-15-11-16-29-83)171-118(200)69-163-135(217)107(62-122(205)206)183-145(227)110-37-25-53-188(110)149(231)108(58-84-30-17-12-18-31-84)184-147(229)125(80(8)190)185-120(202)71-161-132(214)96(42-47-111(152)193)174-130(212)92(151)55-82-26-13-10-14-27-82)140(222)181-105(60-87-64-158-94-35-22-20-33-91(87)94)139(221)168-79(7)129(211)186-124(76(3)4)146(228)164-70-119(201)173-109(73-189)144(226)169-77(5)127(209)167-78(6)128(210)179-103(57-85-38-40-89(192)41-39-85)142(224)177-100(45-50-114(155)196)138(220)187-126(81(9)191)148(230)178-97(46-51-121(203)204)133(215)160-66-115(197)159-67-116(198)172-104(59-86-63-157-93-34-21-19-32-90(86)93)143(225)176-98(43-48-112(153)194)136(218)175-99(44-49-113(154)195)137(219)182-106(61-88-65-156-74-166-88)134(216)162-68-117(199)170-95(36-23-24-52-150)131(213)165-72-123(207)208,3-2(4,5)1(6)7/h10-22,26-35,38-41,63-65,74-81,92,95-110,124-126,157-158,189-192H,23-25,36-37,42-62,66-73,150-151H2,1-9H3,(H2,152,193)(H2,153,194)(H2,154,195)(H2,155,196)(H,156,166)(H,159,197)(H,160,215)(H,161,214)(H,162,216)(H,163,217)(H,164,228)(H,165,213)(H,167,209)(H,168,221)(H,169,226)(H,170,199)(H,171,200)(H,172,198)(H,173,201)(H,174,212)(H,175,218)(H,176,225)(H,177,224)(H,178,230)(H,179,210)(H,180,223)(H,181,222)(H,182,219)(H,183,227)(H,184,229)(H,185,202)(H,186,211)(H,187,220)(H,203,204)(H,205,206)(H,207,208),(H,6,7)/t77-,78-,79-,80+,81+,92-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,124-,125-,126-,/m0./s1. InChi Key: JSGGJTPYPTZEGY-VEEFTMMJSA-N.