Kisspeptin-54 (human) (trifluoroacetate salt)

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively). It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-54 (10-1,000 nM) inhibits insulin secretion from isolated mouse pancreatic beta-cells in the presence of 2.8 mM, but not 11.1 mM, glucose. Kisspeptin-54 (1-5 nmol, i.c.v.) increases serum levels of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in mice, an effect which is reversed by the gonadotropin releasing hormone (GNRH) antagonist acycline.Formal Name: G protein-coupled receptor GPR54 (human), trifluoroacetate salt. Synonyms: Kp-54, Metastin. Molecular Formula: C258H401N79O78 . XCF3COOH. Formula Weight: 5857.4. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC(CNC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@@H](NC([C@H](CC5=CC=C(C=C5)O)NC([C@@H](NC([C@@H]6CCCN6C([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC(CNC([C@@H](NC([C@@H]7CCCN7C([C@H](C)NC([C@@H]8CCCN8C([C@@]([H])(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC9=CN=CN9)NC([C@@H]%10CCCN%10C([C@H](C)NC([C@@H](NC([C@@H](NC(CNC([C@@H]%11CCCN%11C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]%12CCCN%12C([C@@H]%13CCCN%13C([C@@H]%14CCCN%14C([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC(CN[H])=O)[C@H](O)C)=O)CO)=O)CC(C)C)=O)CO)=O)=O)=O)=O)CCC(O)=O)=O)CO)=O)CO)=O)=O)CO)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC(N)=O)=O)=O)=O)CC(C)C)=O)CO)=O)=O)=O)=O)CO)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)[C@@H](C)CC)=O)=O)=O)=O)CCC(N)=O)=O)=O)=O)C(C)C)=O)CC(C)C)=O)C(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(O)=O)=O)CCCCN)=O)=O)CC(C)C)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)=O)CC(N)=O)=O)CO)=O)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C258H401N79O78.C2HF3O2/c1-21-131(16)204(329-220(381)152(70-77-189(264)351)301-213(374)147(53-34-84-281-257(274)275)299-234(395)173(118-341)322-226(387)164(103-140-110-278-123-288-140)315-242(403)181-58-38-87-331(181)247(408)133(18)290-232(393)172(117-340)321-222(383)158(95-125(4)5)293-197(359)114-287-238(399)178-55-36-88-332(178)249(410)155(71-78-190(265)352)306-218(379)150(68-75-187(262)349)300-212(373)146(52-33-83-280-256(272)273)298-233(394)171(116-339)294-198(360)113-286-210(371)170(115-338)319-237(398)175(120-343)320-219(380)154(73-80-200(363)364)304-241(402)183-60-40-90-334(183)252(413)185-62-43-93-337(185)253(414)184-61-42-92-336(184)251(412)177(122-345)325-223(384)159(96-126(6)7)308-236(397)176(121-344)324-246(407)205(135(20)346)326-194(356)108-260)254(415)335-91-41-56-179(335)239(400)291-134(19)248(409)330-86-37-57-180(330)240(401)303-149(67-74-186(261)348)208(369)284-111-195(357)289-132(17)207(368)327-202(129(12)13)245(406)317-160(97-127(8)9)231(392)328-203(130(14)15)244(405)305-151(69-76-188(263)350)216(377)296-145(51-32-82-279-255(270)271)211(372)302-153(72-79-199(361)362)217(378)295-144(50-30-31-81-259)215(376)314-168(107-201(365)366)230(391)318-169(98-128(10)11)250(411)333-89-39-59-182(333)243(404)316-167(106-193(268)355)228(389)310-162(101-138-63-65-141(347)66-64-138)224(385)312-165(104-191(266)353)227(388)311-163(102-139-109-283-143-49-29-28-48-142(139)143)225(386)313-166(105-192(267)354)229(390)323-174(119-342)235(396)309-161(100-137-46-26-23-27-47-137)209(370)285-112-196(358)292-157(94-124(2)3)221(382)297-148(54-35-85-282-258(276)277)214(375)307-156(206(269)367)99-136-44-24-22-25-45-136,3-2(4,5)1(6)7/h22-29,44-49,63-66,109-110,123-135,144-185,202-205,283,338-347H,21,30-43,50-62,67-108,111-122,259-260H2,1-20H3,(H2,261,348)(H2,262,349)(H2,263,350)(H2,264,351)(H2,265,352)(H2,266,353)(H2,267,354)(H2,268,355)(H2,269,367)(H,278,288)(H,284,369)(H,285,370)(H,286,371)(H,287,399)(H,289,357)(H,290,393)(H,291,400)(H,292,358)(H,293,359)(H,294,360)(H,29. InChi Key: GXLHFMZZYDEULZ-OQIIGJSWSA-N.