JB-1 (trifluoroacetate salt)

JB-1 is an insulin-like growth factor 1 receptor (IGF-1R) antagonist and a cyclic derivative of IGF-1 (60-70). It inhibits IGF-1-induced IGF-1R autophosphorylation and proliferation in BALB/c 3T3 cells overexpressing IGF-1R when used at a concentration of 1 µg/ml. Intracerebroventricular administration of JB-1 (4 µg/animal) reduces estradiol- and progesterone-induced increases in serum luteinizing hormone (LH) levels in ovariohysterectomized rats. It also decreases lordosis behavior in the same rats. JB-1 inhibits oxygen-induced decreases in body weight and increases in retinal vascular overgrowth in a neonatal rat model of oxygen-induced retinopathy. InChI: InChI=1S/C55H88N14O15S2.C2HF3O2/c1-29(2)24-38-49(77)63-37(13-7-9-21-57)54(82)69-23-11-14-42(69)51(79)60-31(4)45(73)62-36(12-6-8-20-56)47(75)66-40(26-70)50(78)67-41(55(83)84)28-86-85-27-35(58)46(74)64-39(25-33-16-18-34(71)19-17-33)48(76)59-30(3)44(72)61-32(5)53(81)68-22-10-15-43(68)52(80)65-38,3-2(4,5)1(6)7/h16-19,29-32,35-43,70-71H,6-15,20-28,56-58H2,1-5H3,(H,59,76)(H,60,79)(H,61,72)(H,62,73)(H,63,77)(H,64,74)(H,65,80)(H,66,75)(H,67,78)(H,83,84),(H,6,7)/t30-,31-,32-,35-,36-,37-,38-,39-,40-,41-,42-,43-,/m0./s1, InChIKey: IWFHEUONBROAAH-XOQGUAMSSA-N, SMILES: O=C([C@@H](NC([C@@H](NC([C@@]1([H])N(C([C@@H](NC([C@@H](NC([C@@H](NC2=O)CC(C=C3)=CC=C3O)=O)C)=O)C)=O)CCC1)=O)CC(C)C)=O)CCCCN)N4[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC[C@@H]2N)C(O)=O)=O)CO)=O)CCCCN)=O)C)=O)([H])CCC4.OC(C(F)(F)F)=O