IRBP (1-20) (human, rat) (trifluoroacetate salt)

Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20) is a dodecapeptide fragment of IRBP, also known as retinoid-binding protein 3, which is involved in pigment regeneration by transporting retinol and retinal from photoreceptor cells to the retinal pigment epithelium. IRBP1-20 has been used to induce autoimmune uveoretinitis in C57BL/6 mice, which bear the H-2b haplotype. IRBP1-20 (3 µM) increases the levels of IL-4, IL-5, and IL-6 secreted from primary mouse spleen lymphocytes. Immunization and rechallenge with IRBP1-20 increases ear swelling, ocular blood vessel inflammation, immune cell infiltration, and photoreceptor layer damage, as well as retinal detachment, in IFN-gamma-deficient mice.Formal Name: glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-alpha-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-L-aspartic acid, trifluoroacetate salt. Synonyms: Interphotoreceptor Retinoid-Binding Protein (1-20), IRBP1-20. Molecular Formula: C101H164N24O28S . XCF3COOH. Formula Weight: 2194.6. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: GPTHLFQPSLVLDMAKVLLD-OH. Solubility: 10% ACN/H2O: Soluble. SMILES: OC(C(F)(F)F)=O.O=C(N1CCC[C@H]1C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC2=CNC=N2)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N3CCC[C@H]3C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)=O)=O)CN[H]. InChi Code: InChI=1S/C101H164N24O28S.C2HF3O2/c1-50(2)37-64(112-91(142)70(43-60-47-105-49-106-60)118-99(150)82(58(16)127)123-96(147)74-28-23-34-124(74)77(129)46-103)86(137)114-69(42-59-25-19-18-20-26-59)90(141)110-63(30-31-76(104)128)100(151)125-35-24-29-75(125)95(146)120-73(48-126)94(145)113-68(41-54(9)10)93(144)122-81(56(13)14)98(149)117-67(40-53(7)8)88(139)115-71(44-78(130)131)92(143)109-62(32-36-154-17)84(135)107-57(15)83(134)108-61(27-21-22-33-102)85(136)121-80(55(11)12)97(148)116-66(39-52(5)6)87(138)111-65(38-51(3)4)89(140)119-72(101(152)153)45-79(132)133,3-2(4,5)1(6)7/h18-20,25-26,47,49-58,61-75,80-82,126-127H,21-24,27-46,48,102-103H2,1-17H3,(H2,104,128)(H,105,106)(H,107,135)(H,108,134)(H,109,143)(H,110,141)(H,111,138)(H,112,142)(H,113,145)(H,114,137)(H,115,139)(H,116,148)(H,117,149)(H,118,150)(H,119,140)(H,120,146)(H,121,136)(H,122,144)(H,123,147)(H,130,131)(H,132,133)(H,152,153),(H,6,7)/t57-,58+,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,80-,81-,82-,/m0./s1. InChi Key: JDYFAJISXKDZRH-SELZNHQNSA-N.