Influenza A (H1N1) HA Peptide Pool

Pool of 139 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Hemagglutinin (UniProt ID: C3W5S1) of Influenza A virus (strain swl A/California/04/2009 H1N1) One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin- independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. [The UniProt Consortium]