HUMAN WT1 Peptide Pool

Peptide pool of 110 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Wilms tumor protein (WT33) (Swiss-Prot ID: P19544) of Homo sapiens (Human) for T cell assays (e.g. ELISPOT). One unit allows the stimulation of 2,5 x 10^8 cells. You can find applications and references in our blog: FACS analysis showed: CMV-specific T cells respond to leukemia antigen > Protein function: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921). [The UniProt Consortium]