HUMAN MAGED1 Peptide Pool

Pool of 192 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Melanoma-associated antigen D1 (MAGED1, UniProt: Q9Y5V3) of Homo sapiens for T cell assays (e.g. ELISPOT). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. [The UniProt Consortium]