HUMAN IGF2BP3 Peptide Pool

Pool of 142 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through IGF2 mRNA-binding protein 3 (UniProt ID: O00425) for T cell assays. One unit allows the stimulation of 2,5 x 10^8 cells.You can find applications and references in our blog post: Esophagogastric adenocarcinoma: Tumor-associated antigens, immune responses and HLA-I Expression Protein function: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. [The UniProt Consortium]