HHV5 UL44 Peptide Pool

Pool of 106 peptides derived from a peptide scan (15mers with 11 aa overlap) through DNA polymerase processivity factor (Uni-Prot ID P16790) of Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Accessory subunit of the DNA polymerase that plays an essential role in viral DNA replication and acts by increasing the processivity of polymerization (PubMed:20538862, PubMed:20739543, PubMed:33967989). Forms dimers that binds to double-stranded DNA and UL54 specifically to stimulates long chain DNA synthesis efficiently. Plays an important role in maintaining the structure of viral replication compartments by interacting with host nucleolin/NUC (PubMed:22318319). In addition, suppresses innate immune responses through effects on host IRF3 and NF-kappa-B. Mechanistically, interfere with the binding of IRF3 and the p65 NF-kappa-B subunit to the promoters of antiviral genes, thereby inhibiting the expression of these genes (PubMed:30867312). [The UniProt Consortium]