H-Ala-Glu-Asp-OH

H-Ala-Glu-Asp-OH (AED) is a synthetic tripeptide with geroprotective effects in vitro. It increases proliferation and reduces apoptosis in young and aged rat skin fibroblast cultures but reduces matrix metalloproteinase-9 (MMP-9) levels only in young cultures. AED (20 ng/ml) increases sirtuin 1 (SIRT1), SIRT6, and collagen I levels in young and aged human skin fibroblast cultures. It also prevents mortality in a mouse model of cisplatin-induced acute kidney injury (AKI) when administered at a dose of 3 µg/kg.. SMILES: OC(C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC([C@@H](N)C)=O)=O)=O. InChi Code: InChI=1S/C12H19N3O8/c1-5(13)10(20)14-6(2-3-8(16)17)11(21)15-7(12(22)23)4-9(18)19/h5-7H,2-4,13H2,1H3,(H,14,20)(H,15,21)(H,16,17)(H,18,19)(H,22,23)/t5-,6-,7-/m0/s1. InChi Key: KXEVYGKATAMXJJ-ACZMJKKPSA-N