GPR110 peptide agonist P12

Description: GPR110 peptide agonist P12 is a peptide that acts as an agonist for GPR110. This compound markedly enhances the initial rate of G protein GTPgammaS binding stimulated by GPR110. It mimics the action of the natural ligand, causing the extracellular domain (ECD) of GPR110 to dissociate from the seven-transmembrane domain (7TM) and exposing the N-terminal beta-strand-13/stalk region of the 7TM domain, which acts as the agonist activating G protein signaling. GPR110 peptide agonist P12 is applicable in research related to developmental disorders and cancers associated with GPR110. Smiles: C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(=O)N2[C@H](C(O)=O)CCC2)[C@@H](C)C)=O)(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CO)=O)=O)CO)=O)[C@H](CC)C)=O)CC(C)C)=O)CCSC)=O)CO)=O)CCC3