GnRH II (trifluoroacetate salt)

Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR). It binds to human recombinant type I and marmoset type II GnRHRs (IC50s = 26.1 and 1.07 nM, respectively, in COS-7 cells) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively). GnRH II stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively) and dose-dependently stimulates LH and FSH release from cultured primary rat anterior pituitary cells. In vivo, GnRH II (1 µg/kg, i.v.) increases plasma LH levels in White Leghorn pullets but does not affect plasma FSH levels. It also decreases food intake in zebrafish and increases courtship behavior in female white-crowned sparrows when administered intracerebroventricularly at doses of 1 pmol/g and 100 ng, respectively.Formal Name: 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-histidylglycyl-L-tryptophyl-L-tyrosyl-L-prolyl-glycinamide, trifluoroacetate salt. Synonyms: Gonadotropin-releasing Hormone II, LHRH II. Molecular Formula: C60H69N17O13 . XCF3COOH. Formula Weight: 1236.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC(CNC([C@@H]1CCCN1C([C@H](CC2=CC=C(C=C2)O)NC([C@H](CC3=CNC4=C3C=CC=C4)NC(CNC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CC8=CN=CN8)N(C([C@@H]9CCC(N9)=O)=O)[H])=O)=O)CO)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C60H69N17O13.C2HF3O2/c61-50(80)27-66-59(89)49-10-5-17-77(49)60(90)47(18-32-11-13-37(79)14-12-32)75-55(85)43(19-33-23-64-40-8-3-1-6-38(33)40)71-52(82)28-67-53(83)45(21-35-25-62-30-68-35)73-58(88)48(29-78)76-56(86)44(20-34-24-65-41-9-4-2-7-39(34)41)72-57(87)46(22-36-26-63-31-69-36)74-54(84)42-15-16-51(81)70-42,3-2(4,5)1(6)7/h1-4,6-9,11-14,23-26,30-31,42-49,64-65,78-79H,5,10,15-22,27-29H2,(H2,61,80)(H,62,68)(H,63,69)(H,66,89)(H,67,83)(H,70,81)(H,71,82)(H,72,87)(H,73,88)(H,74,84)(H,75,85)(H,76,86),(H,6,7)/t42-,43-,44-,45-,46-,47-,48-,49-,/m0./s1. InChi Key: GPUUYIZPODSIMD-OWXBLSBESA-N.