Gly-Arg-Gly-Asp-Ser-Pro (trifluoroacetate salt)

Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is an RGD-containing integrin-blocking peptide. It inhibits integrin alpha5beta1 and integrin alphaVbeta3 (IC50s = 200 and 20 nM, respectively). GRGDSP (1 nM) induces chemotaxis of primary human foreskin fibroblasts (HFFs). It reduces angiogenesis induced by basic FGF (bFGF) in a chick chorioallantoic membrane (CAM) assay when used at a concentration of 10 µg/egg. GRGDSP (10 µg/animal) decreases tumor volume and increases survival in a collagen-induced paclitaxel-resistant MCF-7 breast cancer mouse xenograft model. Formal Name: glycyl-L-arginylglycyl-L-alpha-aspartyl-L-seryl-L-proline, trifluoroacetate salt. Molecular Formula: C22H37N9O10  XCF3COOH. Formula Weight: 587.6. Purity: >98%. Formulation (Request formulation change): A solid. Peptide Sequence: GRGDSP-OH. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml PBS (pH 7.2): Soluble: > 10 mg/ml. SMILES: N=C(N)NCCC[C@H](NC(CN)=O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C22H37N9O10.C2HF3O2/c23-8-15(33)28-11(3-1-5-26-22(24)25)18(37)27-9-16(34)29-12(7-17(35)36)19(38)30-13(10-32)20(39)31-6-2-4-14(31)21(40)41,3-2(4,5)1(6)7/h11-14,32H,1-10,23H2,(H,27,37)(H,28,33)(H,29,34)(H,30,38)(H,35,36)(H,40,41)(H4,24,25,26),(H,6,7)/t11-,12-,13-,14-,/m0./s1. InChi Key: SVJVLOLHIALTGU-ZMNOQRQPSA-N. Storage: -20°C. Stability: > 4 years.