GLP-1 (28-36) amide (trifluoroacetate salt)

Glucagon-like peptide 1 (GLP-1) (28-36) amide is a peptide and an active metabolite of the endogenous GLP-1R agonist GLP-1 (7-36) amide (Cay-15069). It is formed from GLP-1 (7-36) amide by neprilysin (NEP). GLP-1 (28-36) amide (100 nM) inhibits decreases in ATP levels induced by hydrogen peroxide and increases in reactive oxygen species (ROS) levels induced by tert-butyl hydroperoxide (t-BHP) in primary mouse hepatocytes and H-4-II-E hepatoma cells. It reduces body weight gain, the ratio of weight gain to food intake, and hepatic gluconeogenesis in a mouse model of obesity induced by a high-fat diet (HFD) when administered at a dose of 18.5 nmol/kg per day. GLP-1 (28-36) amide decreases plasma levels of glucose and insulin and hepatic triglyceride levels in a mouse model of obesity induced by a very high-fat diet (VHFD) when infused at a rate of 18.5 nmol/kg per day.Formal Name: L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-argininamide, trifluoroacetate salt. Synonyms: Glucagon-like Peptide 1 (28-36) amide, Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2. Molecular Formula: C54H85N15O9 . XCF3COOH. Formula Weight: 1088.4. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: FIAWLVKGR-NH2. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, Chloroform: Slightly Soluble: 0.1-1 mg/ml, Methanol: Slightly Soluble: 0.1-1 mg/ml. SMILES: [H]N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)CC3=CC=CC=C3.FC(F)(F)C(O)=O. InChi Code: InChI=1S/C54H85N15O9.C2HF3O2/c1-8-32(6)45(69-48(73)37(56)26-34-17-10-9-11-18-34)53(78)63-33(7)47(72)66-42(27-35-28-61-38-20-13-12-19-36(35)38)50(75)67-41(25-30(2)3)51(76)68-44(31(4)5)52(77)65-40(21-14-15-23-55)49(74)62-29-43(70)64-39(46(57)71)22-16-24-60-54(58)59,3-2(4,5)1(6)7/h9-13,17-20,28,30-33,37,39-42,44-45,61H,8,14-16,21-27,29,55-56H2,1-7H3,(H2,57,71)(H,62,74)(H,63,78)(H,64,70)(H,65,77)(H,66,72)(H,67,75)(H,68,76)(H,69,73)(H4,58,59,60),(H,6,7)/t32-,33-,37-,39-,40-,41-,42-,44-,45-,/m0./s1. InChi Key: AJGPKINDFLQSCY-OPOSQYSSSA-N.