Gap 27 (trifluoroacetate salt)

Gap 27 is a connexin-mimetic peptide that corresponds to amino acids 204-214 of extracellular loop 2 in connexin 43. It reduces survival of isolated rat osteoclasts when used at a concentration of 500 µM and decreases bone resorption in rat bone slice and osteoclast co-cultures. Gap 27 accelerates wound closure and stratification of the corneal epithelium in isolated human corneas. In vivo, Gap 27 reduces cardiac remodeling and the incidence of cardiac arrhythmias in a rat model of arterio-venous fistula (AV-shunt) surgery-induced high-output heart failure.Formal Name: L-seryl-L-arginyl-L-prolyl-L-threonyl-L-alpha-glutamyl-L-lysyl-L-threonyl-L-isoleucyl-L-phenylalanyl-L-isoleucyl-L-isoleucine, trifluoroacetate salt. Synonyms: 43Gap27, SRPTEKTIFII. Molecular Formula: C60H101N15O17 . XCF3COOH. Formula Weight: 1304.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: slightly soluble, Methanol: slightly soluble. SMILES: OC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C60H101N15O17.C2HF3O2/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76,3-2(4,5)1(6)7/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65),(H,6,7)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-,/m0./s1. InChi Key: LNQZFDMFMBAXIK-MSUQGPFSSA-N.