Galanin (human) (acetate)

Human galanin is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist. It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50 = 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2 receptors (EC50 = 12.3 nM). Human galanin induces contractions in isolated rat longitudinal fundus strips with an EC50 value of 13.8 nM. Intrathecal administration of human galanin (3, 10, and 30 nmol/animal) reduces paw licking and flinching in the second, but not first, phase of the formalin test in rats.Formal Name: glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-valylglycyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-alpha-aspartyl-L-lysyl-L-asparaginylglycyl-L-leucyl-L-threonyl-L-serine, acetate. Synonyms: GAL (human), Galanin (1-30). Molecular Formula: C139H210N42O43 . XC2H4O2. Formula Weight: 3157.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(NCC(N4CCC[C@H]4C(N[C@@H](CC5=CNC=N5)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CO)C(O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CN[H].CC(O)=O. InChi Code: InChI=1S/C139H210N42O43.C2H4O2/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224,1-2(3)4/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149),1H3,(H,3,4)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-,/m0./s1. InChi Key: FNXCSWYQOJWUOE-WOKBQIAPSA-N.