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Product information "Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)"
Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay). It selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor). Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats. It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.Formal Name: L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucinamide, trifluoroacetate salt. Synonyms: AR-M1896, Gal(2-11)-NH2, WTLNSAGYLL-NH2. Molecular Formula: C54H81N13O14 . XCF3COOH. Formula Weight: 1136.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml. SMILES: N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)CC(C=C1)=CC=C1O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C54H81N13O14.C2HF3O2/c1-26(2)17-37(46(57)73)62-49(76)38(18-27(3)4)63-51(78)40(20-31-13-15-33(70)16-14-31)61-44(72)24-59-47(74)29(7)60-53(80)42(25-68)66-52(79)41(22-43(56)71)64-50(77)39(19-28(5)6)65-54(81)45(30(8)69)67-48(75)35(55)21-32-23-58-36-12-10-9-11-34(32)36,3-2(4,5)1(6)7/h9-16,23,26-30,35,37-42,45,58,68-70H,17-22,24-25,55H2,1-8H3,(H2,56,71)(H2,57,73)(H,59,74)(H,60,80)(H,61,72)(H,62,76)(H,63,78)(H,64,77)(H,65,81)(H,66,79)(H,67,75),(H,6,7)/t29-,30+,35-,37-,38-,39-,40-,41-,42-,45-,/m0./s1. InChi Key: ILTGGRBAWMAFAK-DQGGFSSQSA-N.
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