ERalpha17p

Description: ERalpha17p (ERalpha 295-311), the epitope of the CaM binding site located on estrogen receptor alpha (ER), interacts with calmodulin (CaM) in a calcium-dependent fashion. This peptide is involved in regulating the migration of various cancer cell lines including MCF-7, SK-BR-3, T47D, and MDA-MB-231 via the Rho/ROCK and PI3K/Akt signaling pathways. Additionally, ERalpha17p plays a role in suppressing proliferation and inducing apoptosis in breast cancer cells, as well as inhibiting tumor growth in mouse models. Target: Apoptosis. Smiles: [C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CC(C)C)=O)CO)=O)CC(C)C)=O)C)=O)CC(C)C)=O)CO)=O)CC(N)=O)=O)CCCCN)=O)CCCCN)=O)CO)=O)CCCNC(=N)N)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@H]1CCCN1)CC(C)C)=O)CCSC)=O)[C@H](CC)C)=O)CCCCN