DT-109

DT-109 is a tripeptide. It reduces blood glucose levels in an oral glucose tolerance test (OGTT) in mice. DT-109 (1 mg/g per day) reduces non-fasting blood glucose levels, serum total cholesterol and LDL levels, and adipocyte hypertrophy in Apo-/- mice. It reduces body fat mass, adipocyte hypertrophy, and hepatomegaly in a mouse model of diet-induced non-alcoholic steatohepatitis (NASH). DT-109 (500 mg/kg per day) also reverses hepatic steatosis and prevents the progression of fibrosis in a cynomolgus monkey model of NASH induced by a high-fat, high-fructose, and high-cholesterol diet.Formal Name: glycylglycyl-L-leucine. CAS Number: 14857-82-0. Synonyms: Gly-Gly-L-Leu. Molecular Formula: C10H19N3O4. Formula Weight: 245.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml. SMILES: NCC(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O. InChi Code: InChI=1S/C10H19N3O4/c1-6(2)3-7(10(16)17)13-9(15)5-12-8(14)4-11/h6-7H,3-5,11H2,1-2H3,(H,12,14)(H,13,15)(H,16,17)/t7-/m0/s1. InChi Key: XPJBQTCXPJNIFE-ZETCQYMHSA-N.