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Davunetide is a neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP). It promotes tubulin assembly in a cell-free assay when used at a concentration of 1 fM. Davunetide (1 fM) protects against cytotoxicity induced by tetrodotoxin (Cay-14963, Cay-14964), a peptide derived from amyloid-beta (Abeta), or zinc in isolated neonatal cerebral cortical cells. Intravitreal administration of davunetide (4 µl of a 100 µg/ml solution) inhibits increases in cleaved caspase-3 and decreases in Bcl-2 levels in retina isolated from streptozotocin-induced diabetic rats. It improves survival in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at 10 µg/animal. Davunetide prevents decreases in brain choline acetyltransferase (ChAT) activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration.Formal Name: L-asparaginyl-L-alanyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine, acetate. Synonyms: AL-108, NAP, NAPVSIPQ. Molecular Formula: C36H60N10O12 . XC2H4O2. Formula Weight: 824.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): 10 mg/ml. SMILES: O=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O.CC(O)=O. InChi Code: InChI=1S/C36H60N10O12.C2H4O2/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49,1-2(3)4/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58),1H3,(H,3,4)/t18-,19-,20-,21-,22-,23-,24-,27-,28-,/m0./s1. InChi Key: FKFJZZGKZSKPFE-XVHDDEJMSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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