Dalazatide HCl

Description: Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells, and can be used for the study of autoimmune diseases. Target: Potassium Channel. Smiles: [H]N[C@@H](CC1=CC=C(C=C1)O)C(NC(C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@]([H])(C(N[C@@H](CC(O)=O)C(N[C@]([H])(C(N[C@]([H])(C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@]([H])(C(N[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CS)C(N[C@H](C(N[C@H](C(N[C@]([H])(C(N[C@@H](CS)C(NCC(N[C@]([H])(C(N[C@@H](CS)C(O)=O)=O)[C@H](O)C)=O)=O)=O)[C@H](O)C)=O)CCCCN)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)=O)CO)=O)=O)CCCCN)=O)=O)CCC(N)=O)=O)=O)=O)[C@H](O)C)=O)=O)CCCNC(N)=N)=O)CO)=O)CCCCN)=O)=O)[C@@H](C)CC)=O)[C@H](O)C)=O)=O)[C@@H](C)CC)=O)=O)CO)=O)CCCNC(N)=N)=O)[R])=O.Cl. References: Tyagi A, et al. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc Natl Acad Sci U S A. 2022 Feb 1,119(5):e2113536119.