(D)-PPA 1 (trifluoroacetate salt)

(D)-PPA 1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1). It binds to the extracellular domain of PD-L1 (Kd = 0.51 µM for the recombinant human protein). (D)-PPA 1 (2 mg/kg) decreases tumor volume and improves survival in a CT26 murine colorectal cancer model.Formal Name: D-asparaginyl-D-tyrosyl-D-seryl-D-lysyl-D-prolyl-D-threonyl-D-alpha-aspartyl-D-arginyl-D-glutaminyl-D-tyrosyl-D-histidyl-D-phenylalanine, trifluoroacetate salt. Synonyms: DPPA-1, NYSKPTDRQYHF. Molecular Formula: C70H98N20O21 . XCF3COOH. Formula Weight: 1555.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 10 mg/mL, Ethanol: Slightly soluble, PBS (pH 7.2): 5 mg/mL. SMILES: OC(C=C1)=CC=C1C[C@@H](NC([C@H](N)CC(N)=O)=O)C(N[C@H](CO)C(N[C@H](CCCCN)C(N2[C@H](CCC2)C(N[C@H]([C@@H](O)C)C(N[C@H](CC(O)=O)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCC(N)=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C70H98N20O21.C2HF3O2/c1-36(92)57(89-66(107)53-13-8-26-90(53)68(109)46(11-5-6-24-71)82-65(106)52(34-91)88-62(103)47(27-38-14-18-41(93)19-15-38)83-58(99)43(72)31-55(74)96)67(108)86-50(32-56(97)98)64(105)80-44(12-7-25-78-70(75)76)59(100)81-45(22-23-54(73)95)60(101)84-48(28-39-16-20-42(94)21-17-39)61(102)85-49(30-40-33-77-35-79-40)63(104)87-51(69(110)111)29-37-9-3-2-4-10-37,3-2(4,5)1(6)7/h2-4,9-10,14-21,33,35-36,43-53,57,91-94H,5-8,11-13,22-32,34,71-72H2,1H3,(H2,73,95)(H2,74,96)(H,77,79)(H,80,105)(H,81,100)(H,82,106)(H,83,99)(H,84,101)(H,85,102)(H,86,108)(H,87,104)(H,88,103)(H,89,107)(H,97,98)(H,110,111)(H4,75,76,78),(H,6,7)/t36-,43+,44+,45+,46+,47+,48+,49+,50+,51+,52+,53+,57+,/m0./s1. InChi Key: WFYLZRHZVBLQEG-MPGWZRFHSA-N.