Cyclosporin B

Description: Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also inhibits RANKL-induced TRAP phosphatase activity, inducing apoptosis in osteoclasts. Cyclosporin B is a derivative of cyclosporin A that exhibits significantly less immunosuppressive activity. Smiles: C\C=C\C[C@@H](C)[C@@H](O)[C@@H]1N(C)C(=O)C(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](C)NC1=O)C(C)C. References: Jansen Of Lorkeers SJ, Hart E, Tang XL, Chamuleau ME, Doevendans PA, Bolli R, Chamuleau SA. Cyclosporin in cell therapy for cardiac regeneration. J Cardiovasc Transl Res. 2014 Jul,7(5):475-82. doi: 10.1007/s12265-014-9570-8. Epub 2014 May 16. Review. PubMed PMID: 24831573, PubMed Central PMCID: PMC4435776.