Cyclo(L-Trp-L-Trp)

Cyclo(L-Trp-L-Trp) is a cyclic dipeptide that has been used as a substrate for indole prenyltransferases in the synthesis of mono- and diprenylated indolines. It has antibacterial activity and inhibits growth of 41 out of 49 strains of multidrug resistant A. baumannii (MICs = 12.5-25 µg/ml) as well as B. subtilis, M. luteus, S. aureus, S. cerevisiae, A. niger, and C. albicans (MICs = 12.5-50 µg/ml). Prenylated forms of cyclo(L-Trp-L-Trp) are cytotoxic against human leukemia and ovarian cell lines.Formal Name: 3S,6S-bis(1H-indol-3-ylmethyl)-2,5-piperazinedione. CAS Number: 20829-55-4. Synonyms: Cyclic dioxopiperazine-L-tryptophan-L-tryptophan. Molecular Formula: C22H20N4O2. Formula Weight: 372.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 5 mg/ml. lambdamax: 221, 281, 291 nm. SMILES: O=C([C@H](CC1=CNC2=C1C=CC=C2)N3)N[C@@H](CC4=CNC5=C4C=CC=C5)C3=O. InChi Code: InChI=1S/C22H20N4O2/c27-21-19(9-13-11-23-17-7-3-1-5-15(13)17)25-22(28)20(26-21)10-14-12-24-18-8-4-2-6-16(14)18/h1-8,11-12,19-20,23-24H,9-10H2,(H,25,28)(H,26,27)/t19-,20-/m0/s1. InChi Key: DNHODRZUCGXYKU-PMACEKPBSA-N.