CP-EPS8-NLS (trifluoroacetate salt)

A cell-penetrating peptide inhibitor of EPS8 nuclear translocation, induces apoptosis and cell cycle arrest in the G0/G1 phase in THP-1, HL-60, and U937 cells at 70 µM, reduces phosphorylated ERK, STAT3, and Akt levels in THP-1, HL-60, and U937 cells at 35 or 70 µM, reduces tumor volume without affecting body weight in a U937 mouse xenograft model at 55 mg/kg every other day, decreases tumor volume alone or in combination with daunorubicin in a KG-1 AML mouse xenograft model at 50 mg/kg every other day. Formulation: A solid. InChI: InChI=1S/C135H256N62O30.C2HF3O2/c1-76(199)173-73-103(203)176-80(39-20-62-165-128(149)150)108(208)179-81(33-5-14-56-139)111(211)180-83(35-7-16-58-141)113(213)184-89(42-23-65-168-131(155)156)116(216)186-91(44-25-67-170-133(159)160)118(218)191-93(49-51-100(145)200)121(221)188-90(43-24-66-169-132(157)158)117(217)187-92(45-26-68-171-134(161)162)119(219)193-95(46-27-69-172-135(163)164)126(226)197-71-29-48-99(197)127(227)196-70-28-47-98(196)125(225)192-94(50-52-101(146)201)122(222)195-97(75-198)124(224)190-85(37-9-18-60-143)114(214)185-88(41-22-64-167-130(153)154)115(215)181-82(34-6-15-57-140)112(212)182-86(38-10-19-61-144)120(220)194-96(72-102(147)202)123(223)189-84(36-8-17-59-142)110(210)178-78(31-3-12-54-137)106(206)174-74-104(204)175-79(32-4-13-55-138)107(207)183-87(40-21-63-166-129(151)152)109(209)177-77(105(148)205)30-2-11-53-136,3-2(4,5)1(6)7/h77-99,198H,2-75,136-144H2,1H3,(H2,145,200)(H2,146,201)(H2,147,202)(H2,148,205)(H,173,199)(H,174,206)(H,175,204)(H,176,203)(H,177,209)(H,178,210)(H,179,208)(H,180,211)(H,181,215)(H,182,212)(H,183,207)(H,184,213)(H,185,214)(H,186,216)(H,187,217)(H,188,221)(H,189,223)(H,190,224)(H,191,218)(H,192,225)(H,193,219)(H,194,220)(H,195,222)(H4,149,150,165)(H4,151,152,166)(H4,153,154,167)(H4,155,156,168)(H4,157,158,169)(H4,159,160,170)(H4,161,162,171)(H4,163,164,172),(H,6,7)/t77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,/m0./s1. InChIKey: NICGITHBVFHNPE-BAACNABTSA-N. SMILES: FC(F)(F)C(O)=O.NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O