Citrullinated alpha-Enolase (R8 + R14) (1-19)-biotin Peptide

Citrullinated alpha-Enolase (R8 + R14) (1-19)-biotin peptide is a biotinylated and citrullinated form of a 19-amino acid N-terminal peptide fragment of alpha-enolase, a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. alpha-Enolase also functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription. alpha-Enolase is an autoantigen in asthma, Hashimoto's encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis. alpha-Enolase is also subject to citrullination by peptidyl arginine deiminases (PADs) and citrullinated alpha-enolase has been found in the synovial fluid of rheumatoid arthritis patients. Cayman's Citrullinated alpha-Enolase (R8 + R14) (1-19)-biotin Peptide is intended for use in the detection of autoantibodies against alpha-enolase citrullinated at R8 and R13.Synonyms: Citrullinated Enolase-1-biotin, alpha-Enolase Peptide (Citrulline Residues 8 + 14). MW: 2,381.5. Formulation: (Request formulation change), 1 mg of lyophilized peptide. UniProt Accession #: P06733.