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Product information "Chemerin-9 (human) (acetate)"
Chemerin-9 is a peptide agonist of chemokine-like receptor 1 (CMKLR1) and CMKLR2, also known as chemerin receptor 1 (chemerin1) and chemerin2, respectively. It is composed of nine C-terminal amino acids of the endogenous human protein chemerin, a chemotactic protein and adipokine involved in the early immune response and energy homeostasis. Chemerin-9 binds to CMKLR1 and CMKLR2 (IC50s = 1.9 and 2.3 nM, respectively, in a radioligand binding assay) and induces calcium mobilization in HEK293T cells expressing either CMKLR1 or CMKLR2 and the G protein Galpha15 when used at a concentration of 1 µM.Formal Name: L-tyrosyl-L-phenylalanyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-serine, acetate. Synonyms: Chemerin (149-157), YFPGQFAFS. Molecular Formula: C54H66N10O13 . XC2H4O2. Formula Weight: 1063.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 16 mg/ml, DMSO: 12 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.3 mg/ml. SMILES: O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@@H](CO)C(O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)[C@@H](NC([C@@H](N)CC(C=C4)=CC=C4O)=O)CC5=CC=CC=C5.CC(O)=O. InChi Code: InChI=1S/C54H66N10O13.C2H4O2/c1-32(47(69)60-41(28-34-14-7-3-8-15-34)51(73)63-43(31-65)54(76)77)58-50(72)40(27-33-12-5-2-6-13-33)61-49(71)39(23-24-45(56)67)59-46(68)30-57-52(74)44-18-11-25-64(44)53(75)42(29-35-16-9-4-10-17-35)62-48(70)38(55)26-36-19-21-37(66)22-20-36,1-2(3)4/h2-10,12-17,19-22,32,38-44,65-66H,11,18,23-31,55H2,1H3,(H2,56,67)(H,57,74)(H,58,72)(H,59,68)(H,60,69)(H,61,71)(H,62,70)(H,63,73)(H,76,77),1H3,(H,3,4)/t32-,38-,39-,40-,41-,42-,43-,44-,/m0./s1. InChi Key: HJEXDFJBTIHVPO-CPIFIIIUSA-N.
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