CALP1 (trifluoroacetate salt)

CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site. It binds to calmodulin (Kd = 88 µM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 µM) and apoptosis (IC50 = 44.78 µM). CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma. It also decreases radical production induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings.Formal Name: L-valyl-L-alanyl-L-isoleucyl-L-threonyl-L-valyl-L-leucyl-L-valyl-L-lysine, trifluoroacetate salt. Synonyms: Calcium-like Peptide 1. Molecular Formula: C40H75N9O10 . XCF3COOH. Formula Weight: 842.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: O=C([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)C(C)C)=O)CC(C)C)=O)C(C)C)=O)[C@@H](C)O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C40H75N9O10.C2HF3O2/c1-13-23(10)31(48-33(51)24(11)43-35(53)28(42)20(4)5)38(56)49-32(25(12)50)39(57)47-30(22(8)9)37(55)45-27(18-19(2)3)34(52)46-29(21(6)7)36(54)44-26(40(58)59)16-14-15-17-41,3-2(4,5)1(6)7/h19-32,50H,13-18,41-42H2,1-12H3,(H,43,53)(H,44,54)(H,45,55)(H,46,52)(H,47,57)(H,48,51)(H,49,56)(H,58,59),(H,6,7)/t23-,24-,25+,26-,27-,28-,29-,30-,31-,32-,/m0./s1. InChi Key: NEQKOMDEJDLJON-KIFCWDIHSA-N.