Bradykinin (human, mouse, rat, bovine) (acetate)

Bradykinin is an endogenous vasodilator that is also involved in inflammation. It is formed from kininogen via cleavage of high molecular weight kininogen (HMWK) by kallikrein or prekallikrein in a Factor XIIa-dependent or -independent manner. Bradykinin binds to the bradykinin B2 receptor (IC50 = 0.54 nM in COS-7 cells expressing the human receptor) and acts as an agonist but does not bind the bradykinin B1 receptor (Ki = >10,000 nM in HEK293 cells expressing the human receptor). It stimulates arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) release in CHO cells expressing the human bradykinin B2 receptor (EC50 = 0.7 nM). Bradykinin (100 nM) induces relaxation of isolated porcine coronary arterial rings precontracted with acetylcholine (ACh, Cay-23829) or phorbol 12,13-dibutyrate (PDBu, Cay-27785). It induces hyperalgesia in mice when administered at a dose of 1 µg/paw, an effect that can be reversed by the bradykinin B2 antagonist icatibant (HOE 140, Cay-24083). Plasma levels of bradykinin are increased in patients during an acute attack of angioedema.CAS Number: 6846-03-3. Synonyms: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH, BK, RPPGFSPFR-OH. Molecular Formula: C50H73N15O11 . XC2H4O2. Formula Weight: 1060.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 12 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: CC(O)=O.O=C(N(CCC1)[C@@H]1C(NCC(N[C@H](C(N[C@@H](CO)C(N(CCC2)[C@@H]2C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H](CCC5)N5C([C@@H](N)CCCNC(N)=N)=O. InChi Code: InChI=1S/C50H73N15O11.C2H4O2/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55,1-2(3)4/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57),1H3,(H,3,4)/t32-,33-,34-,35-,36-,37-,38-,39-,/m0./s1. InChi Key: VIGBULRGBBKXHS-MIEKKPBHSA-N.