BAY 55-9837 (trifluoroacetate salt)

BAY 55-9837 is a peptide vasoactive intestinal polypeptide receptor 2 (VPAC2) agonist. It binds to VPAC2 (Kd = 65 nM) and selectively induces cAMP production in CHO cells expressing human VPAC2 over VPAC1 or the PACAP type I (PAC1) receptor (EC50s = 0.4, 100, and >1,000 nM, respectively). BAY 55-9837 (100 nM) increases glucose-dependent insulin secretion in isolated rat and human pancreatic islets. In vivo, BAY 55-9837 enhances glucose-induced insulin secretion in fasted rats (ED50 = ~3 pmol/kg).Formal Name: L-histidyl-L-seryl-L-alpha-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-alpha-aspartyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-valyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-seryl-L-isoleucyl-L-lysyl-L-asparaginyl-L-lysyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt. Molecular Formula: C167H270N52O46 . XCF3COOH. Formula Weight: 3742.3. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: HSDAVFTDNYTRLRKQVAAKKYLQSIKNKRY-NH2. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC(C[C@H](NC([C@H](CO)NC([C@H](CC1=CNC=N1)N[H])=O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C=C2)=CC=C2O)C(N[C@@]([H])([C@@H](C)O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC(C=C3)=CC=C3O)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C=C4)=CC=C4O)C(N)=O)=O)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)C)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C167H270N52O46.C2HF3O2/c1-16-86(10)131(162(263)201-105(39-24-29-63-172)145(246)208-117(74-125(176)229)153(254)197-103(37-22-27-61-170)140(241)196-107(41-31-65-187-166(181)182)143(244)203-111(134(178)235)69-93-43-49-97(224)50-44-93)217-159(260)122(80-221)214-147(248)109(55-57-123(174)227)200-151(252)113(68-83(4)5)205-152(253)114(71-94-45-51-98(225)52-46-94)206-144(245)104(38-23-28-62-171)195-139(240)101(35-20-25-59-168)193-136(237)88(12)190-135(236)87(11)192-160(261)129(84(6)7)216-148(249)110(56-58-124(175)228)199-141(242)102(36-21-26-60-169)194-142(243)106(40-30-64-186-165(179)180)198-150(251)112(67-82(2)3)204-146(247)108(42-32-66-188-167(183)184)202-163(264)132(90(14)222)218-156(257)115(72-95-47-53-99(226)54-48-95)207-154(255)118(75-126(177)230)209-155(256)120(77-128(233)234)212-164(265)133(91(15)223)219-157(258)116(70-92-33-18-17-19-34-92)211-161(262)130(85(8)9)215-137(238)89(13)191-149(250)119(76-127(231)232)210-158(259)121(79-220)213-138(239)100(173)73-96-78-185-81-189-96,3-2(4,5)1(6)7/h17-19,33-34,43-54,78,81-91,100-122,129-133,220-226H,16,20-32,35-42,55-77,79-80,168-173H2,1-15H3,(H2,174,227)(H2,175,228)(H2,176,229)(H2,177,230)(H2,178,235)(H,185,189)(H,190,236)(H,191,250)(H,192,261)(H,193,237)(H,194,243)(H,195,240)(H,196,241)(H,197,254)(H,198,251)(H,199,242)(H,200,252)(H,201,263)(H,202,264)(H,203,244)(H,204,247)(H,205,253)(H,206,245)(H,207,255)(H,208,246)(H,209,256)(H,210,259)(H,211,262)(H,212,265)(H,213,239)(H,214,248)(H,215,238)(H,216,249)(H,217,260)(H,218,257)(H,219,258)(H,231,232)(H,233,234)(H4,179,180,186)(H4,181,182,187)(H4,183,184,188),(H,6,7)/t86-,87-,88-,89-,90+,91+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,129-,130-,131-,132-,133-,/m0./s1. InChi Key: JIQKRJDXBDWPCS-WDCXZJHUSA-N.