ARF(26âEUR"44)

Description: ARF(26â?"44), cell-permeable is an anti-tumor peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. It serves as an inhibitor of FoxM1, a forkhead box M1 transcription factor, and has demonstrated significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC). This activity includes increasing apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26â?"44), cell-permeable is useful for research in cancer therapy. Target: Apoptosis. Smiles: C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)[C@@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)C(C)C)=O)=O)C)=O)CC(C)C)=O)C)=O)CS)=O)CO)=O)C)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC2