Aquaporin-4, human Peptide Pool

Pool of 78 peptides derived from a peptide scan (15mers with 11 aa overlap) through Aquaporin-4 protein (Uni-Prot ID P55087) of Homo sapiens (Human). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. [The UniProt Consortium]