Antileukinate

Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and beta-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.Formal Name: N2-acetyl-L-arginyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-cysteinyl-L-argininamide. CAS Number: 138559-60-1. Molecular Formula: C45H66N18O7S. Formula Weight: 1003.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 222, 282, 290 nm. SMILES: CC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CS)=O)=O)=O)=O)CCCNC(N)=N)=O. InChi Code: InChI=1S/C45H66N18O7S/c1-24(64)58-32(14-7-17-54-44(49)50)38(66)60-33(15-8-18-55-45(51)52)39(67)61-34(19-25-21-56-29-11-4-2-9-27(25)29)40(68)62-35(20-26-22-57-30-12-5-3-10-28(26)30)41(69)63-36(23-71)42(70)59-31(37(46)65)13-6-16-53-43(47)48/h2-5,9-12,2. InChi Key: FVRBFNYUBYTVIQ-NGTAMTFRSA-N.