alpha-MSH (11-13) (trifluoroacetate salt)

alpha-MSH (11-13) is a peptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH, Item No. 29923), a neuropeptide with anti-inflammatory and immunomodulatory activity. It is bactericidal against methicillin-resistant S. aureus (MRSA) with ~10% survival when used at a concentration of 1 µM. alpha-MSH (11-13) (2.5%, w/v in the drinking water) reduces colonic inflammation and the time to regain body weight in a mouse model of colitis induced by dextran sulfate (DSS, Item No. 23250). It also increases survival in mice expressing nonfunctional melanocortin receptor 1 (MC1Re/e mice) in a DSS-induced colitis model, indicating that the effect is independent of MC1R. alpha-MSH (11-13) reduces microglial activation, neuronal apoptosis, and lesion volume in a mouse model of traumatic brain injury (TBI) when administered 30 minutes post-injury at a dose of 1 mg/kg.. SMILES: CC(C)[C@@H](C(O)=O)NC([C@@H]1CCCN1C([C@H](CCCCN)N)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C16H30N4O4.C2HF3O2/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17,3-2(4,5)1(6)7/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24),(H,6,7)/t11-,12-,13-,/m0./s1. InChi Key: HNJIMIOIAVEIIV-QKWXXBCPSA-N