(Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt)

(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 µM, respectively). It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. (Ala1)-PAR4 (1-6) amide (mouse) induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips (EC50s = 11 and 110 µM, respectively) as well as inhibits calcium mobilization evoked by capsaicin (Cay-92350) in rat sensory neurons. In vivo, (Ala1)-PAR4 (1-6) amide (mouse) (1-100 µg) increases latency to paw withdrawal and the nociceptive threshold in response to thermal and mechanical stimuli. (Ala1)-PAR4 (1-6) amide (mouse) (200 µg) also increases paw thickness in a rat paw edema assay.Formal Name: L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide, trifluoroacetate salt. Synonyms: AY-NH2, AYPGKF-NH2, H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2, PAR4-AP, Proteinase-Activated Receptor 4 Activating Peptide. Molecular Formula: C34H48N8O7 . XCF3COOH. Formula Weight: 680.8. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: NC([C@@H](NC([C@H](CCCCN)NC(CNC([C@H]1N(C([C@H](CC2=CC=C(O)C=C2)NC([C@H](C)N)=O)=O)CCC1)=O)=O)=O)CC3=CC=CC=C3)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22,3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46),(H,6,7)/t21-,25-,26-,27-,28-,/m0./s1. InChi Key: BGPJLFVICWHITH-HKJXYENISA-N.