ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate)

Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH (Cay-24257), a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor (IC50 = ~1 nM in HeLa cells expressing the mouse receptor). It induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively. Unlike ACTH (4-11) (Cay-27430), ACTH (11-24) does not induce differentiation of primary mouse melanocytes. In vivo, ACTH (11-24) (1.69 µg/animal, i.c.v.) inhibits ACTH-induced stretching, yawning, and penile erections in rats.Formal Name: alpha11-24-corticotropin, acetate. Synonyms: alpha11-24-ACTH, Adrenocorticotropic Hormone (11-24), Corticotropin (11-24). Molecular Formula: C77H134N24O16 . XC2H4O2. Formula Weight: 1652.0. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: KPVGKKRRPVKVYP-OH. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: O=C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(O[H])C=C3)C(N4CCC[C@H]4C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H].CC(O)=O. InChi Code: InChI=1S/C77H134N24O16.C2H4O2/c1-44(2)60(97-67(108)56-26-17-39-99(56)72(113)49(82)20-7-11-33-78)69(110)89-43-59(103)90-50(21-8-12-34-79)63(104)91-51(22-9-13-35-80)64(105)92-53(24-15-37-87-76(83)84)65(106)94-54(25-16-38-88-77(85)86)73(114)100-40-18-27-57(100)68(109)98-62(46(5)6)70(111)93-52(23-10-14-36-81)66(107)96-61(45(3)4)71(112)95-55(42-47-29-31-48(102)32-30-47)74(115)101-41-19-28-58(101)75(116)117,1-2(3)4/h29-32,44-46,49-58,60-62,102H,7-28,33-43,78-82H2,1-6H3,(H,89,110)(H,90,103)(H,91,104)(H,92,105)(H,93,111)(H,94,106)(H,95,112)(H,96,107)(H,97,108)(H,98,109)(H,116,117)(H4,83,84,87)(H4,85,86,88),1H3,(H,3,4)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,60-,61-,62-,/m0./s1. InChi Key: FCUKBHOCSHSSNE-WKYQKWCMSA-N.