A11

Description: A11 (ANXA1-derived 11 amino acidâ?"long peptide) serves as an inhibitor of the ANXA1-EphA2 interaction, reducing ANXA1 attachment to EphA2 while promoting the association of Cbl (an E3 ubiquitin ligase of EphA2) with EphA2. This peptide also effectively lowers EphA2 levels, greatly enhances EphA2 ubiquitination, and stimulates EphA2 internalization along with the colocalization of EphA2 and Cbl in nasopharyngeal carcinoma (NPC) cells. Moreover, A11 curtails NPC cell proliferation, migration, and invasion, and it suppresses angiogenesis. Target: Ephrin Receptor. Smiles: [C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CO)=O)CO)=O)CCCCN)=O)[C@@H](C)C)=O)[C@@H](C)O)=O)CCC(N)=O)=O)C(C)C)=O)NC([C@H](CCC(O)=O)N)=O