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Cyclic(YCDGFYACYMDV)
Item number: TGM-TP3053-10mg
Description: Cyclic(YCDGFYACYM DV) is a HER2 signaling pathway inhibitor with anticancer properties. In aqueous solution, Cyclic(YCDGFYACYMDV) self-assembles into nanoparticles that target HER2 on cancer cells, converting into nanofibrils. This process disrupts HER2 dimerization and subsequent downstream signaling,...
| MW: | 1447.61 D |
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Ac-MRGDH-NH2
Item number: TGM-TP3057-10mg
Description: Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Lambda- and Delta-[Ru(Ph2phen)2(kappaS,kappaN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua...
| MW: | 655.727 D |
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RSRGVFF
Item number: TGM-TP3062-10mg
Description: RSRGVFF (FOXP3 inhibitor P60) is a mixed angiotensin-converting enzyme (ACE) inhibitor with the ability to penetrate the blood-brain barrier, exhibiting an IC50 value of 5.01 µM. It binds to both active and inactive sites of ACE and its substrate HHL complex, thereby reducing the catalytic activity of...
| MW: | 867.994 D |
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RES-701-1
Item number: TGM-TP3073-10mg
Description: RES-701-1 is a cyclic peptide consisting of 16 common L-amino acids. It acts as a specific antagonist of the ETB receptor. RES-701-1 inhibits the binding of 125I-ET-1 (125I-labeled endothelin (ET)-1) to the ETB receptor, with an IC50 value of 10 nM. Target: Endothelin Receptor. Smiles:...
| MW: | 2043.16 D |
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LAG-3 cyclic peptide inhibitor 12
Item number: TGM-TP3077-10mg
Description: LAG-3cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3, exhibiting an IC50 of 4.45 µM and a Ki of 2.66 µM. Target: LAG-3. Smiles:...
| MW: | 1050.28 D |
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VAMP
Item number: TGM-TP3084-10mg
Description: VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 µM and a Kd of 6.89 µM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes. Target: Proteasome. Smiles:...
| MW: | 416.535 D |
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CPI1
Item number: TGM-TP3085-10mg
Description: CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP...
| MW: | 2299.43 D |
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UK140
Item number: TGM-TP3092-10mg
Description: UK140 is an inhibitor of the urokinase-type plasminogen activator (uPA), with Ki values of 0.20 µM for human uPA (huPA) and 2.79 µM for mouse uPA (muPA). UK140 is applicable in studies related to tumor metastasis. Target: PAI-1. Smiles:...
| MW: | 1732.91 D |
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tLyP-1 peptide
Item number: TGM-TP3105-10mg
Description: tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 µM, and its amino acid sequence is CGNKRTR. It can specifically bind to NRP-1 to target tumor cells. Target: Complement System. Smiles:...
| MW: | 833.96 D |
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ETTAC-2
Item number: TGM-TP3119-10mg
Description: ETTAC-2 is an LRG1 PROTAC degrader that facilitates the ubiquitination and degradation of LRG1, with a DC50 of 8.38 µM. It inhibits the TGF-beta-Smad3 signaling pathway and reduces the secretion of proteins associated with fibrosis. ETTAC-2 can slow the progression of renal fibrosis. Target: PROTACs,...
| MW: | 1891.07 D |
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HYNIC-UBI29-41
Item number: TGM-TP3130-10mg
Description: HYNIC-UBI29-41 is composed of the bifunctional chelator HYNIC and the antimicrobial peptide UBI 29-41. It retains the antimicrobial properties of UBI 29-41, showing strong affinity for both Gram-positive and Gram-negative bacteria. When labeled with the radioactive element Technetium (99mTc),...
| MW: | 1828.07 D |
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GeX-2
Item number: TGM-TP3132-10mg
Description: GeX-2 is a truncated analogue of alphaO-conotoxin. It has the ability to activate GABAB receptors and inhibit alpha9alpha10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury. Target: Calcium Channel, AChR, GABA Receptor....
| MW: | 2441.72 D |
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